Rab GTPases coordinate endocytosis

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Rab GTPases coordinate endocytosis.

Endocytosis is characterized by vesicular transport along numerous pathways. Common steps in each pathway include membrane budding to form vesicles, transport to a particular destination, and ultimately docking and fusion with the target membrane. Specificity of vesicle targeting is rendered in part by associated Rab GTPases. This review summarizes current knowledge about Rab GTPase functions i...

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There was an error published in J. Cell Sci. 120, 3905-3910. The authors regret that in Table 1 under ‘(13) Rab1, Rab3, Rab8, Rab10, Rab12, Rab13, Rab15, Rab35, Rab40’, Rab35 was incorrectly referred to as an uncharacterized member of the Rab family. The correct details are given below. Rab Localization Function Reference Rab35 Plasma membrane, endosomes, intercellular bridge Rapid endocytic re...

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Rab proteins are a family of small GTPases which, since their initial identification in the late 1980s, have emerged as master regulators of all stages of intracellular trafficking processes in eukaryotic cells. Rabs cycle between distinct conformations that are dependent on their guanine-nucleotide-bound status. When active (GTP-bound), Rabs are distributed to the cytosolic face of specific me...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2000

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.113.2.183